The effect of type and concentration of vehicles on the. Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. Several formulations of liquisolid compacts having different drug concentration 30% to 50% ww. International journal of research in pharmaceutical and nano sciences. Among the various liquisolid compacts were prepared, the formulation f2 i. Solubility and dissolution improvement use of nonvolatile solvent causes increased wettability and ensures molecular dispersion of poorly soluble, liquid, insoluble or lipophilic drug. Pdf liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs.
International journal of research pharmaceutical and nano. This technique is applied to poorly water soluble, water insoluble or. Ramyadevi school of chemical and biotechnology, sastra university, thanjavur 6 401, tamil nadu, india corres. Avicel ph 102, aerosil200 were employed as carrier and coating materials. Liquisolid technique is novel concept of the drug delivery via the oral route. Fabrication and characterization of liquisolid compacts of. This research work has produced encouraging invitro dissolution of poorly soluble drugs such as liquisolid technology.
Liquisolid technique is a new and promising method that can change the dissolution rate of drugs. Download product information and specifications to find out everything about our radiators. Us6096337a liquisolid systems and methods of preparing. Then a mixture of carrier avicel ph 102 was added to the above liquid by continuous mixing for a.
Enhancement of ketoconazole dissolution rate by the. Formulation and characterization of ketoprofen liquisolid. For this purpose the liquisolid compacts with fixed liquid medication with different amounts of powder substrate 570 % were formulated. Liquisolid compacts containing propylene glycol as vehicle produced higher dissolution rates in comparison with liquisolid compacts. Ali nokhodchi 1 department of pharmacy, school of health and life sciences, kings college london, london, united kingdom. Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan. The in vitro release study was performed on those compacts. A novel approach to enhance solubility and bioavailability download download pdf. Formulation and characterization of liquisolid compacts of.
This technique is a promising alternative for formulation of waterinsoluble solid drugs and liquid drugs. From this study it was concluded that the liquisolid technique is a promising alternative for improvement of dissolution property of waterinsoluble drugs. The preformulation studies like melting point, flow. The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug indomethacin from liquisolid compacts. All of the stelrad downloads you need in one place. Telmisartan is an angiotensin ii receptor antagonist arb used in the management of hypertension. Sustainedrelease liquisolid compact tablets containing.
Liquisolid compacts were prepared by using, propylene glycol, tween 20 as the nonvolatile liquid vehicles. Evaluation of liquisolid compacts formulation the prepared liquisolid compacts were evaluated for carrying out various tests such as assay, content uniformity, friability, weight variation, hardness and disintegration. Liquisolid technique as a tool for enhancement of poorly. Formulation and evaluation of loperamide liquisolid compacts. Research article formulation and evaluation of liquisolid. Liquisolid compacts were prepared using polyethylene glycol 400, neusilin us2 and aerosil 200. The formulations were evaluated for drug excipient interactions, change in crystallinity of drug, flow.
According to the new formulation method of liquisolid compacts, liquid medications such as. The term liquisolid microsystems refers to capsules prepared by combining the drug with carrier and coating materials with inclusion of an additive e. Formulation and evaluation of liquisolid compacts for. Development of liquisolid compacts is one of the new pharmaceutical formulation technologies to improve the dissolution rate of poorly soluble drugs.
Orodispersible liquisolid system is the combination of liquisolid technique and orodispersible system. Liquisolid technique for dissolution rate enhancement of a high dose waterinsoluble drug carbamazepine yousef javadzadeha,b, baharak jafarinavimipoura, ali nokhodchib,c. Schematic outline of the steps involved in the preparation of liquisolid compacts. Different liquisolid compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce acceptable and free flowing compressible mixtures. The wettability of the compacts in the dissolution media is one of the proposed mechanisms for explaining the enhanced dissolution rate from the liquisolid compacts. Use of the liquisolid compact technique for improvement of the. Olmesartan medoxomil was received as a gi sample from alembic pharma ltd. The drug content of liquisolid compacts was not affected when stored at room temperature for a period of 3 months. Pharmatutor journal, pharma journal, submit articles return to article details orodispersible liquisolid compacts.
For comparison purposes physical mixtures of all ingredients were prepared. Martinas physical pharmacy and pharmaceutical sciences. Based on the literatures, liquisolid technique has been widely used to improve the dissolution rate of low dose insoluble drugs, such as prednisolone, famotidine, valsartan, ketoprofen, raloxifene hydrochloride, clonazepam, clofibrate, etc. The objective of the present work was to obtain ph independent and improved dissolution profile for a poorly soluble drug, telmisartan using liquisolid compacts. Enhancement of loperamide dissolution rate by liquisolid. Dec 14, 2016 a more recent technique, powdered solution technology or liquisolid technology, has been applied to prepare waterinsoluble drugs into rapidrelease solid dosage forms.
According to the concept of liquisolid systems, liduid lipophilic drugs, or waterinsoluble solid drugs dissolved in suitable nonvolatile solvents, may be converted into freeflowing and readily compressible powders by a simple admixture with selected powder excipients referred to as the carrier. In liquisolid compact, a liquid medication is converted into acceptably flowing and compactible powder forms. In liquisolid systems, the drug is already in solution form in liquid vehicle, while at the same time, it is carried by powder. Formulation and evaluation of nimodipine tablet by liquisolid. The compacts were prepared using capryol 90 as nonvolatile solvent, neusilin as carrier and aerosil 200 as coating material. The most popular online tool to compress pdf files into an email ready size. Liquisolid compact ls8 was showing the best release. Nonvolatile solvent present in the liquisolid system facilitates wetting of drug particles by decreasing interfacial tension between dissolution medium and tablet surface javadzadeh y et al. Liquisolid technique, flowability, dissolution, liquid load factor. Abstact liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable. A funnel was secured with its tip at a given height h above a graph paper.
Student of master of pharmacy, department of pharmaceutics, a one pharmacy college, enasan, ahmedabad, gujarat, india 2. Yousef javadzadeh, mohammad reza siahishadbad, mohammad barzegarjalali. A more recent technique, powdered solution technology or liquisolid technology, has been applied to prepare waterinsoluble drugs into rapidrelease solid dosage forms. Stability studies showed that there were no significant changes in physical and chemical properties of a tablet of formulation ls8 after 3 months. Author links open overlay panel chella naveen a c nalini shastri. The term liquisolid compacts technique refers to process of preparation of immediate or sustained release tablets or capsules using the liquisolid systems. Liquisolid compacts based orodispersible tablets to enhance. The effect of powder substrate composition on the flowability and compressibility of liquisolid compacts were evaluated. Liquisolid compact is one of the emerging techniques that enhances the dissolution of poorly water soluble drugs. The aim of present study was to improve the dissolution rate of poorly soluble drugloperamide lpm by liquisolid compact technique. Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan 503. In the present study, the potential of liquisolid systems to improve the dissolution properties of waterinsoluble agents was investigated using diclofenac sodium as the model drug. Liquisolid technique as a tool to enhance drug dissolution.
Liquisolid compacts based orodispersible tablets to. Low aqueous solubility is one of the major reasons for the poor clinical efficacy of carvedilol in oral therapy. Student of master of pharmacy, department of pharmaceutics, a one. Free to use, without the need to register an account or email address. The poor dissolution rate of water insoluble drug is a major drawback for the development of pharmaceutical dosage forms. The technique of liquisolid preparation is used to formulate drug solution in solid dosage forms. Liquisolid compacts of lpm were prepared using propylene glycol pg as asolvent, avicel ph 102 as carrier, aerosil as coating material and sodium starch glycolatessg as superdisintegrant. Oct 12, 2014 the objective of the present work was to obtain ph independent and improved dissolution profile for a poorly soluble drug, telmisartan using liquisolid compacts. The technique of liquisolid compacts is a promising method towards enhancing the dissolution of poorly soluble drugs. Use of the liquisolid compact technique for improvement of.
An approach to enhance the dissolution rate of nimesulide srinivas vaskula, sateesh kumar vemula, vijaya kumar bontha and prasad garrepally the present study enlightens to enhance the dissolution rate, absorption efficiency and bioavailability of nimesulide, a poorly solublehighly permeable drug by preparing liquisolid. Keywords glibenclamide, liquisolid, liquid load factor, excipient ratio and carrier and coating material. Flow properties of liquisolid powders fixed funnel and the freestanding cone method were employed to measure the angle of repose. The flowability of a powder is of critical importance in the production of pharmaceutical dosage forms. Sustainedrelease liquisolid compact tablets containing artemetherlumefantrine as alternateday regimen for malaria treatment to improve patient compliance petra obioma nnamani,1,2 agatha adaora ugwu,1 emmanuel chinedu ibezim,1 franklin chimaobi kenechukwu,1 paul achile akpa,1 johndike nwabueze ogbonna,1 nicholas chinedu obitte,3 amelia ngozi odo,4 maike windbergs,2 claus. In the present investigation, an attempt was made to improve the dissolution properties of water insoluble herbal active ingredient, embelin ebn by utilizing liquisolid technique, which might offer improved bioavailability. Ramipril liquisolid systems were prepared and compressed into tablets of 20 mg strength each, using a single punching machine with the aim of the desired hardness of 36 kgcm2. All liquisolid formulations powder and silica as the coating material at a fixed powder excipient ratio r of 20. Formulation, optimization and evaluation of liquisolid tablets containing tadalafil malani ketan ashokbhai, dr. All tests were carried out according to the usp compendial specifications. Download each file individually, or you can download all of your files at once in a zip archive.
Liquisolid compacts refers to immediate sustainedrelease tablets or capsules that are described under liquisolid systems 2 liquisolidmicrosystems refers to capsules prepared by liquisolid systems with the inclusion of an additive resulting in a unit size that may be as much as five times less than that of a liquisolid compact. Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing compressible powders by blending with selected powder excipents. Several studies have shown that the liquisolid technique is a promising method for promoting dissolution rate of poorly water soluble drugs28. Avicel ph 102 was used as the carrier and aerosil 200 as a coating material and sodium starch glycolate as the disintegrant respectively. Liquisolid technique is a new and promising method that can change the dissolution rate of water insoluble drugs. Formulation and evaluation of liquisolid compacts of. Transformation into an amorphous form having highest energy and solubility. Liquisolid technique and its applications in pharmaceutics.
According to the liquisolid methodology, liquid medications in solutions or suspension form of water insoluble drugs in suitable nonvolatile liquid solvent can be converted into readily. Liquisolid compacts were prepared using propylene glycol as solvent, avicel ph102 as carrier, and aerosil 200 as the. Us6096337a liquisolid systems and methods of preparing same. Preparation and characterization of liquisolid compacts. Liquisolid compacts were prepared using transcutol hp as vehicle, avicel ph102 as carrier, and aerosil 200 as a coating material. Preparation of conventional tablet and liquisolid compacts the liquisolid compacts were prepared according to the. This study also provided evidence that it is possible to load high amounts of drug into liquisolid compacts due to the neusilin allows higher liquid adsorption capacities. Formulation and evaluation of liquisolid compacts of carvedilol. The liquisolid compact improved the dissolution up to 95% while the solid dispersion increased it to 88%. The term liquisolid systems ls is a powdered form of liquid drug formulated by converting liquid or solid lipophilic drug in suitable nonvolatile solvent systems into dry looking, nonadherent, freeflowing, and readily compressible. Liquisolid systems and methods of preparing same spireas. The prepared liquisolid compacts were evaluated for their flow. According to the concept of liquisolid systems, liquid lipophilic drugs, or waterinsoluble solid drugs dissolved in suitable nonvolatile solvents, may be converted into freeflowing and readily compressible powders by a simple admixture with selected powder excipients referred to as the.
The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate. Flow properties are the important concern in the formulation and industrial production of tablet dosage form. Liquisolid microsystems liquisolid compacts are prepared using the previously outlined method to produce tablets or capsules, whereas the liquisolid micro systems are based on a new concept which to produce an acceptably flowing admixture for encapsulations. The liquisolid compact system is a novel concept of drug delivery that can change the dissolution rate of water. Specifically, several liquisolid formulations, containing 10mg tadalafil, which containing different carrier to coating ratios in their. The results showed that aging had no significant effect on disso lution profiles of liquisolid tablets. Figure 1 shows lower contact angle of liquisolid compacts than the conventional. From the literature, it was evident that aerosil 200 was a nongritty amorphous powder22. The intent of present investigation was to enhance the dissolution rate of poorly soluble drug flurbiprofen by delivering the drug as a liquisolid compact. Liquisolid compacts based orodispersible tablets to enhance solubility of atorvastatin using experimental design raj shah1, hardeep banwait2, sahjesh rathi2, pragnesh patni3 1. Liquisolid compacts were developed using polyethylene glycol 400 peg 400 as solvent, avicel ph102 or starch or hpmc or peg 4000 or peg 6000 as the carrier powder and aerosil 200 as the coating material.
Avicel, carbamazepine, dissolution enhancement, fujicalin, liquisolid compact, neusilin. The term liquisolid compacts refers to immediate or. Liquisolid compact technique for improvementof the. This online pdf compressor allows to compress pdf files without degrading the resolution dpi, thus keeping your files printable and zoomable.
Liquisolid compacts were prepared using propylene glycol as solvent, avicel ph102 as carrier, and aerosil 200 as. Liquisolid compact technology authorstream presentation. This technique of liquisolid compacts has been successfully employed to improve the invitro release of poorly water soluble drugs. Then the formed liquisolid compact is characterized and evaluated by ftir, drug content and in vitro dissolution studies. Liquisolid technique as an approach was developed to sustain the drug release from matrix compacts. Preand postcompression studies of ketoprofen liquisolid compacts. Liquisolid compacts liquisolid microsystems liquisolid compacts are prepared using the previously outlined method to produce tablets or capsules, whereas the liquisolid microsystems are based on a new concept which to produce an acceptably flowing admixture for encapsulations. The aim of the present investigation was to evaluate the potential of liquisolid compact technique to enhance the dissolution rates of carvedilol and thereby the bioavailability. May 30, 2018 orodispersible liquisolid system is the combination of liquisolid technique and orodispersible system. Formulation and evaluation of carbamazepine liquisolid compacts. Preparation and characterization of liquisolid compacts for. Applications of liquisolid technique in pharmaceutics 5. Increasing the peg400todrug ratio in liquid medications enhanced the dissolution rate remarkably.
Improvement of oral bioavailability of carvedilol by. The final mixture should be compressed using the manual tabletting. Design and development of liquisolid compact of candesartan. The results obtained indicated that liquisolid compact formulations were more effective in enhancing the dissolution rate compared with solid dispersion technique. A novel approach to enhance bioavailability of poorly. Orodissolving systems of papaya extract liquisolid compacts and lozenges athul sundaresan, r. The crystallinity of the newly formulated drug and the. The oral absorption of drug is most often controlled by dissolution in the gastrointestinal tract.
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